Choline is found in a lot of the foods we eat, but typically not in a large enough dose to have any meaningful benefit. Supplementing with choline alone can be a powerful nootropic because it serves as a direct precursor to acetylcholine—which can improve memory formation. Combining it with piracetam can not only lead to further improvements in memory, but may also help treat neuro-degenerative diseases, like Alzheimer’s and dementia, in the elderly.1,2
- Waegemans, Tony, et al. “Clinical efficacy of piracetam in cognitive impairment: a meta-analysis.” Dementia and geriatric cognitive disorders 13.4 (2002): 217-224.
- Bartus, Raymond T., et al. “Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.” Neurobiology of aging 2.2 (1981): 105-111.
- Wikipedia Choline: https://en.wikipedia.org/wiki/Choline.