Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. It plays a key role in cell cycle signaling, specifically in relationship to apoptosis.

Phosphatidylserine is an important chemical with widespread functions in the body. It’s key in the maintenance of cellular functions, especially within the brain. There’s a decent amount of literature showing its positive effects in elderly individuals both with and without cognition and memory impairments.1,2
Phosphatidylserine has also been shown to improve cognitive function before a bout of exercise.3 By supplementing with phosphatidylserine, individuals may potentially be able to obtain better results from exercise (by staying focused and alert) and at the same time improve mood and mental function.
And for all of you struggling through calculus, supplementing with phosphatidylserine has been shown to increase cognitive function during math problems (faster times completing calculations and increased number of correct answers).
As mentioned above, phosphatidylserine can also blunt the cortisol response following aerobic activity.4 So, not only will you be able to answer the question, “What is the square root of 2 to the negative 9 plus 3 power?” without the use of a calculator, you’ll be able to maintain your muscle mass! TBS Ingredient ID (TBSI ID): IS34F2B0.

Supplements with Phosphatidylserine:


  1. Richter, Yael, et al. “The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study.” Clinical Interventions in aging 5 (2010): 313.
  2. Vakhapova, Veronika, et al. “Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension.” BMC neurology 11.1 (2011): 79.
  3. Parker, Adam G., et al. “The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise.” Journal of the International Society of Sports Nutrition 8.1 (2011): 16.
  4. Starks, Michael A., et al. “The effects of phosphatidylserine on endocrine response to moderate intensity exercise.” Journal of the International Society of Sports Nutrition 5.1 (2008): 11.
  5. Wikipedia Phosphatidylserine:

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