Huperzine A (C15H18N2O) is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata and in varying quantities in other Huperzia species, including H. elmeri, H. carinat, and H. aqualupian.

Huperzine-A is an extract from a Chinese club moss plant that is used to break down the learning neurotransmitter acetylcholine. Acetylcholine is a chemical used by nerves to communicate not only in the brain but in the muscles and other areas of the body as well.

Huperzine-A works as an acetylcholine (AChE) inhibitor and ensures that levels of this chemical don’t fall in the body. By doing so, users experience improved mental clarity, better concentration, superior memory capacity, and protection against age-related memory impairment. In fact, this ingredient is commonly used for Alzheimer’s patients to increase alertness, energy, and memory. More about Huperzine-A on The Best Supplements: The Supplements with Huperzine A (TBS Ingredient ID (TBSI ID): IS345670).

Supplements with Huperzine-A:


  1. Zangara, Andrea. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease.” Pharmacology Biochemistry and Behavior 75.3 (2003): 675-686.
  2. Gordon, Richard K., et al. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.” Chemico-biological interactions 157 (2005): 239-246.
  3. Wikipedia, Huperzine-A: Huperzine-A.

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