Choline is a water-soluble vitamin-like essential nutrient. It is a basic constituent of lecithin, which is present in many plants and animal organs. The term cholines refers to the class of quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation (X− on the right denotes an undefined counteranion).

Choline is found in a lot of the foods we eat, but typically not in a large enough dose to have any meaningful benefit. Supplementing with choline alone can be a powerful nootropic because it serves as a direct precursor to acetylcholine—which can improve memory formation. Combining it with piracetam can not only lead to further improvements in memory, but may also help treat neuro-degenerative diseases, like Alzheimer’s and dementia, in the elderly.1,2

More about Choline on The Best Supplements: The Supplements with Choline (TBS Ingredient ID (TBSI ID): IS32CFD0).


  1. Waegemans, Tony, et al. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis.” Dementia and geriatric cognitive disorders 13.4 (2002): 217-224.
  2. Bartus, Raymond T., et al. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.” Neurobiology of aging 2.2 (1981): 105-111.
  3. Wikipedia, Choline: Choline.

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